@article {4290,
	title = {The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits.},
	journal = {Nature Neuroscience},
	volume = {13},
	year = {2010},
	month = {2010 Nov},
	pages = {1413-20},
	abstract = {<p>The primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the organization of local excitatory connections onto layers 2 and 3 (L2/3) of the mouse A1. Consistent with the organization of other cortical regions, synaptic inputs along the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column. By contrast, we found that local connections along the tonotopic axis differed from those along the isofrequency axis: some input pathways to L3 (but not L2) arose predominantly out-of-column. In vivo cell-attached recordings revealed differences between the sound-responsiveness of neurons in L2 and L3. Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex.</p>
},
	keywords = {Acoustic Stimulation, Adjuvants, Amino Acids, Animals, Anisotropy, Auditory Cortex, Brain Mapping, Cholera Toxin, Confocal, Excitatory Postsynaptic Potentials, Functional Laterality, Glutamic Acid, Immunologic, Inbred C57BL, Inbred CBA, Long-Evans, Mice, Microscopy, Nerve Net, Neural Pathways, Neurons, Newborn, Nonparametric, Photic Stimulation, Psychoacoustics, Rats, Statistics, Time Factors},
	issn = {1546-1726},
	doi = {10.1038/nn.2659},
	author = {Oviedo, Hysell V and Bureau, Ingrid and Svoboda, Karel and Zador, Anthony M}
}
