@article {2752,
	title = {Examining the combinatorial model of motor neuron survival by expression profiling of trophic factors and their receptors in the embryonic Gallus gallus.},
	journal = {Developmental Dynamics: An Official Publication of the American Association of Anatomists},
	volume = {239},
	year = {2010},
	month = {2010 Mar},
	pages = {965-79},
	abstract = {<p>During embryogenesis, limb-innervating lateral motor column (LMC) spinal motor neurons (MN) are generated in excess and subsequently nearly half of them die. Many motor neuron survival factors (MnSFs) have been shown to suppress this default programmed cell death (PCD) program through their receptors (MnSFRs), raising the possibility that they are involved in matching specific MNs with their target muscles. Published observations suggest a combinatorial model of MnSF/Rs function, which assumes that during the PCD phase, MNs are expressing combinations of MnSFRs, whereas the limb muscles innervated by these MNs express cognate combinations of MnSFs. We tested this model by expression profiling of MnSFs and their receptors in the avian lumbosacral spinal cord and limb muscles during the peak PCD period. Our findings highlight the complexity of MnSF/Rs function in the control of LMC motor neuron survival.</p>
},
	keywords = {Animals, Biological, Cell Death, Chick Embryo, Chickens, Computer-Assisted, Developmental, Developmental Biology, DNA Primers, Gene Expression Profiling, Gene Expression Regulation, Image Processing, Ligands, Lumbosacral Region, Models, Motor Neurons, Reverse Transcriptase Polymerase Chain Reaction, Spinal Cord},
	issn = {1097-0177},
	doi = {10.1002/dvdy.22215},
	author = {Gu, Wendy X W and Kania, Artur}
}
@article {2751,
	title = {Identification of genes controlled by LMX1B in E13.5 mouse limbs.},
	journal = {Developmental Dynamics: An Official Publication of the American Association of Anatomists},
	volume = {239},
	year = {2010},
	month = {2010 Aug},
	pages = {2246-55},
	abstract = {<p>During limb development, the dorsal limb mesenchyme expression of the transcription factor LMX1B is required for dorsoventral limb patterning. In mice, Lmx1b mutations result in the mirror-image duplication of ventral limb structures and loss of dorsal limb structures. Heterozygous LMX1B mutations in humans cause the Nail-Patella Syndrome characterized by limb, kidney, and eye developmental defects. We used DNA microarrays to compare the mRNAs in E13.5 mouse Lmx1b mutant and wild-type limbs. We report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb.</p>
},
	keywords = {Animals, Body Patterning, Extremities, Gene Expression, Genes, Homeodomain Proteins, Humans, Messenger, Mice, Oligonucleotide Array Sequence Analysis, RNA, Transcription Factors},
	issn = {1097-0177},
	doi = {10.1002/dvdy.22357},
	author = {Gu, Wendy X W and Kania, Artur}
}
