@article {69882,
	title = {Molecular organization of central cholinergic synapses.},
	journal = {Proc Natl Acad Sci U S A},
	volume = {122},
	year = {2025},
	month = {2025 Apr 29},
	pages = {e2422173122},
	abstract = {<p>Synapses have undergone significant diversification and adaptation, contributing to the complexity of the central nervous system. Understanding their molecular architecture is essential for deciphering the brain{\textquoteright}s functional evolution. While nicotinic acetylcholine receptors (nAchRs) are widely distributed across metazoan brains, their associated protein networks remain poorly characterized. Using in vivo proximity labeling, we generated proteomic maps of subunit-specific nAchR interactomes in developing and mature brains. Our findings reveal a developmental expansion and reconfiguration of the nAchR interactome. Proteome profiling with genetic perturbations showed that removing individual nAchR subunits consistently triggers compensatory shifts in receptor subtypes, highlighting mechanisms of synaptic plasticity. We also identified the Rho-GTPase regulator Still life (Sif) as a key organizer of cholinergic synapses, with loss of Sif disrupting their molecular composition and structural integrity. These results provide molecular insights into the development and plasticity of central cholinergic synapses, advancing our understanding of synaptic identity conservation and divergence.</p>
},
	keywords = {Animals, Brain, Cholinergic Neurons, Drosophila melanogaster, Drosophila Proteins, Neuronal Plasticity, Proteome, Proteomics, Receptors, Nicotinic, Synapses},
	issn = {1091-6490},
	doi = {10.1073/pnas.2422173122},
	url = {https://doi.org/10.1073/pnas.2422173122},
	author = {Rosenthal, Justin S and Zhang, Dean and Yin, Jun and Long, Caixia and Yang, George and Li, Yan and Lu, Zhiyuan and Li, Wei-Ping and Yu, Zhiheng and Li, Jiefu and Yuan, Quan}
}
@article {4299,
	title = {Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall.},
	journal = {Nature},
	volume = {468},
	year = {2010},
	month = {2010 Dec 16},
	pages = {921-6},
	abstract = {<p>Photoreceptors for visual perception, phototaxis or light avoidance are typically clustered in eyes or related structures such as the Bolwig organ of Drosophila larvae. Unexpectedly, we found that the class IV dendritic arborization neurons of Drosophila melanogaster larvae respond to ultraviolet, violet and blue light, and are major mediators of light avoidance, particularly at high intensities. These class IV dendritic arborization neurons, which are present in every body segment, have dendrites tiling the larval body wall nearly completely without redundancy. Dendritic illumination activates class IV dendritic arborization neurons. These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger.</p>
},
	keywords = {Animal Structures, Animals, Avoidance Learning, Cell Surface, Cells, Cultured, Dermis, Drosophila melanogaster, Drosophila Proteins, Invertebrate, Larva, Light, Light Signal Transduction, Neurons, Photoreceptor Cells, Receptors, TRPC Cation Channels},
	issn = {1476-4687},
	doi = {10.1038/nature09576},
	author = {Xiang, Yang and Yuan, Quan and Vogt, Nina and Looger, Loren L and Jan, Lily Yeh and Jan, Yuh Nung}
}
