@article {65092,
	title = {Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor.},
	journal = {Science Advances},
	volume = {5},
	year = {2019},
	month = {2019 Jul 10},
	pages = {eaaw3108},
	abstract = {<p>Neuromodulation plays a critical role in brain function in both health and disease, and new tools that capture neuromodulation with high spatial and temporal resolution are needed. Here, we introduce a synthetic catecholamine nanosensor with fluorescent emission in the near infrared range (1000{\textendash}1300 nm), near infrared catecholamine nanosensor (nIRCat). We demonstrate that nIRCats can be used to measure electrically and optogenetically evoked dopamine release in brain tissue, revealing hotspots with a median size of 2 {\textmu}m. We also demonstrated that nIRCats are compatible with dopamine pharmacology and show D2 autoreceptor modulation of evoked dopamine release, which varied as a function of initial release magnitude at different hotspots. Together, our data demonstrate that nIRCats and other nanosensors of this class can serve as versatile synthetic optical tools to monitor neuromodulatory neurotransmitter release with high spatial resolution.</p>
},
	doi = {10.1126/sciadv.aaw3108},
	url = {http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aaw3108https://syndication.highwire.org/content/doi/10.1126/sciadv.aaw3108},
	author = {Beyene, Abraham G. and Delevich, Kristen and Del Bonis-O{\textquoteright}Donnell, Jackson Travis and Piekarski, David J. and Lin, Wan Chen and Thomas, A. Wren and Yang, Sarah J. and Kosillo, Polina and Yang, Darwin and Prounis, George S. and Wilbrecht, Linda and Landry, Markita P.}
}
@article {4298,
	title = {Structural plasticity underlies experience-dependent functional plasticity of cortical circuits.},
	journal = {The Journal of Neuroscience},
	volume = {30},
	year = {2010},
	month = {2010 Apr 7},
	pages = {4927-32},
	abstract = {<p>The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.</p>
},
	keywords = {Animals, Cerebral Cortex, Dendritic Spines, Inbred C57BL, Learning, Male, Mice, Nerve Net, Neuronal Plasticity, Synapses, Transgenic, Vibrissae},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.6403-09.2010},
	author = {Wilbrecht, Linda and Holtmaat, Anthony and Wright, Nick and Fox, Kevin and Svoboda, Karel}
}
