@article {46595,
	title = {EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior.},
	journal = {PLoS One},
	volume = {9},
	year = {2014},
	month = {2014 Jan 31},
	pages = {e87714},
	abstract = {<p>Epidermal Growth Factor Receptor (EGFR) signaling has a conserved role in ethanol-induced behavior in flies and mice, affecting ethanol-induced sedation in both species. However it is not known what other effects EGFR signaling may have on ethanol-induced behavior, or what roles other Receptor Tyrosine Kinase (RTK) pathways may play in ethanol induced behaviors. We examined the effects of both the EGFR and Fibroblast Growth Factor Receptor (FGFR) RTK signaling pathways on ethanol-induced enhancement of locomotion, a behavior distinct from sedation that may be associated with the rewarding effects of ethanol. We find that both EGFR and FGFR genes influence ethanol-induced locomotion, though their effects are opposite - EGFR signaling suppresses this behavior, while FGFR signaling promotes it. EGFR signaling affects development of the Drosophila mushroom bodies in conjunction with the JNK MAP kinase basket (bsk), and with the Ste20 kinase tao, and we hypothesize that the EGFR pathway affects ethanol-induced locomotion through its effects on neuronal development. We find, however, that FGFR signaling most likely affects ethanol-induced behavior through a different mechanism, possibly through acute action in adult neurons.</p>
},
	keywords = {Animals, Behavior, Animal, Central Nervous System Depressants, Drosophila melanogaster, Drosophila Proteins, Ethanol, Locomotion, Mice, Mushroom Bodies, Receptor, Epidermal Growth Factor, Receptors, Invertebrate Peptide, Signal Transduction},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0087714},
	author = {King, Ian F G and Eddison, Mark and Kaun, Karla R and Heberlein, Ulrike}
}
@article {5486,
	title = {Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {106},
	year = {2009},
	month = {2009 Jul 7},
	pages = {11352-7},
	abstract = {<p>Selection of appropriate oviposition sites is essential for progeny survival and fitness in generalist insect species, such as Drosophila melanogaster, yet little is known about the mechanisms regulating how environmental conditions and innate adult preferences are evaluated and balanced to yield the final substrate choice for egg-deposition. Female D. melanogaster are attracted to food containing acetic acid (AA) as an oviposition substrate. However, our observations reveal that this egg-laying preference is a complex process, as it directly opposes an otherwise strong, default behavior of positional avoidance for the same food. We show that 2 distinct sensory modalities detect AA. Attraction to AA-containing food for the purpose of egg-laying relies on the gustatory system, while positional repulsion depends primarily on the olfactory system. Similarly, distinct central brain regions are involved in AA attraction and repulsion. Given this unique situation, in which a single environmental stimulus yields 2 opposing behavioral outputs, we propose that the interaction of egg-laying attraction and positional aversion for AA provides a powerful model for studying how organisms balance competing behavioral drives and integrate signals involved in choice-like processes.</p>
},
	keywords = {Acetic Acid, Animal, Animal Feed, Animals, Avoidance Learning, Biological, Brain, Drosophila melanogaster, Female, Hydrogen-Ion Concentration, Models, Neurons, Olfactory Pathways, Oviposition, Sexual Behavior, Taste},
	issn = {1091-6490},
	doi = {10.1073/pnas.0901419106},
	author = {Joseph, Ryan M and Devineni, Anita V and King, Ian F G and Heberlein, Ulrike}
}
