@article {6826,
	title = {Cellular and behavioral functions of fruitless isoforms in Drosophila courtship.},
	journal = {Current Biology },
	volume = {24},
	year = {2014},
	month = {2014 Feb 3},
	pages = {242-51},
	abstract = {<p>BACKGROUND: Male-specific products of the fruitless (fru) gene control the development and function of neuronal circuits that underlie male-specific behaviors in Drosophila, including courtship. Alternative splicing generates at least three distinct Fru isoforms, each containing a different zinc-finger domain. Here, we examine the expression and function of each of these isoforms. RESULTS: We show that most fru(+) cells express all three isoforms, yet each isoform has a distinct function in the elaboration of sexually dimorphic circuitry and behavior. The strongest impairment in courtship behavior is observed in fru(C) mutants, which fail to copulate, lack sine song, and do not generate courtship song in the absence of visual stimuli. Cellular dimorphisms in the fru circuit are dependent on Fru(C) rather than other single Fru isoforms. Removal of Fru(C) from the neuronal classes vAB3 or aSP4 leads to cell-autonomous feminization of arborizations and loss of courtship in the dark. CONCLUSIONS: These data map specific aspects of courtship behavior to the level of single fru isoforms and fru(+) cell types-an important step toward elucidating the chain of causality from gene to circuit to behavior.</p>
},
	issn = {1879-0445},
	doi = {10.1016/j.cub.2013.12.015},
	author = {von Philipsborn, Anne C and J{\"o}rchel, Sabrina and Tirian, Laszlo and Demir, Ebru and Morita, Tomoko and Stern, David L and Dickson, Barry J}
}
@article {6860,
	title = {Neuronal control of Drosophila courtship song.},
	journal = {Neuron},
	volume = {69},
	year = {2011},
	month = {2011 Feb 10},
	pages = {509-22},
	abstract = {<p>The courtship song of the Drosophila male serves as a genetically tractable model for the investigation of the neural mechanisms of decision-making, action selection, and motor pattern generation. Singing has been causally linked to the activity of the set of neurons that express the sex-specific fru transcripts, but the specific neurons involved have not been identified. Here we identify five distinct classes of fru neuron that trigger or compose the song. Our data suggest that P1 and pIP10 neurons in the brain mediate the decision to sing, and to act upon this decision, while the thoracic neurons dPR1, vPR6, and vMS11 are components of a central pattern generator that times and shapes the song{\textquoteright}s pulses. These neurons are potentially connected in a functional circuit, with the descending pIP10 neuron linking the brain and thoracic song centers. Sexual dimorphisms in each of these neurons may explain why only males sing.</p>
},
	keywords = {Animal, Animals, Courtship, Drosophila, Drosophila Proteins, Female, Genetically Modified, Male, Nerve Net, Nerve Tissue Proteins, Neurons, Sex Characteristics, Sexual Behavior, Transcription Factors, Vocalization},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2011.01.011},
	author = {von Philipsborn, Anne C and Liu, Tianxiao and Yu, Jai Y and Masser, Christopher and Bidaye, Salil S and Dickson, Barry J}
}
