@article {65316,
	title = {Multiple network properties overcome random connectivity to enable stereotypic sensory responses.},
	journal = {Nature Communications},
	volume = {11},
	year = {2020},
	month = {2020 Feb 24},
	pages = {1023},
	abstract = {<p>Connections between neuronal populations may be genetically hardwired or random. In the insect olfactory system, projection neurons of the antennal lobe connect randomly to Kenyon cells of the mushroom body. Consequently, while the odor responses of the projection neurons are stereotyped across individuals, the responses of the Kenyon cells are variable. Surprisingly, downstream of Kenyon cells, mushroom body output neurons show stereotypy in their responses. We found that the stereotypy is enabled by the convergence of inputs from many Kenyon cells onto an output neuron, and does not require learning. The stereotypy emerges in the total response of the Kenyon cell population using multiple odor-specific features of the projection neuron responses, benefits from the nonlinearity in the transfer function, depends on the convergence:randomness ratio, and is constrained by sparseness. Together, our results reveal the fundamental mechanisms and constraints with which convergence enables stereotypy in sensory responses despite random connectivity.</p>
},
	issn = {2041-1723},
	doi = {10.1038/s41467-020-14836-6},
	author = {Mittal, Aarush Mohit and Gupta, Diksha and Singh, Amrita and Lin, Andrew C and Gupta, Nitin}
}
@article {6899,
	title = {Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination.},
	journal = {Nature Neuroscience},
	volume = {17},
	year = {2014},
	month = {2014 Feb 23},
	pages = {559-68},
	abstract = {<p>Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell odor responses, increased inter-odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated odor coding and thus the odor specificity of memories.</p>
},
	issn = {1546-1726},
	doi = {10.1038/nn.3660},
	author = {Lin, Andrew C and Bygrave, Alexei M and de Calignon, Alix and Lee, Tzumin and Miesenb{\"o}ck, Gero}
}
