@article {2411,
	title = {Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {103},
	year = {2006},
	month = {2006 Feb 21},
	pages = {2594-9},
	abstract = {<p>Cell-type-selective expression of the TFIID subunit TAF(II)105 (renamed TAF4b) in the ovary is essential for proper follicle development. Although a multitude of signaling pathways required for folliculogenesis have been identified, downstream transcriptional integrators of these signals remain largely unknown. Here, we show that TAF4b controls the granulosa-cell-specific expression of the proto-oncogene c-jun, and together they regulate transcription of ovary-selective promoters. Instead of using cell-type-specific activators, our findings suggest that the coactivator TAF4b regulates the expression of tissue-specific genes, at least in part, through the cell-type-specific induction of c-jun, a ubiquitous activator. Importantly, the loss of TAF4b in ovarian granulosa cells disrupts cellular morphologies and interactions during follicle growth that likely contribute to the infertility observed in TAF4b-null female mice. These data highlight a mechanism for potentiating tissue-selective functions of the basal transcription machinery and reveal intricate networks of gene expression that orchestrate ovarian-specific functions and cell morphology.</p>
},
	keywords = {Animals, Developmental, Female, Gene Expression Regulation, Genetic, Gonadotropins, Granulosa Cells, Horses, Messenger, Mice, Mutant Strains, Ovarian Follicle, Ovary, Promoter Regions, Proto-Oncogene Proteins c-jun, Rats, RNA, TATA-Binding Protein Associated Factors, Transcription, Transcription Factor TFIID, Up-Regulation},
	issn = {0027-8424},
	doi = {10.1073/pnas.1100640108},
	author = {Geles, Kenneth G and Freiman, Richard N and Liu, Wei-Li and Zheng, Shuang and Voronina, Ekaterina and Tjian, Robert}
}
