@article {5898,
	title = {Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse.},
	journal = {Journal of Computational Neuroscience},
	volume = {492},
	year = {2005},
	month = {2005 Nov 7},
	pages = {90-100},
	abstract = {<p>Genetic incorporation in a mouse of a transgene containing the prion promoter and the green fluorescent protein (GFP) coding sequence labels a set of substantia gelatinosa (SG) neurons (SG-GFP) homogenous in morphology, electrophysiology, and γ-amino-butyric acid expression. In the present analysis the SG-GFP neurons are established to have protein kinase C-βII immunoreactivity and to lack evidence for the presence of calbindin D-28k, parvalbumin, and protein kinase C-γ. These neurons were hyperpolarized by mediators of descending control, norepinephrine and serotonin. Sequential polymerase chain reactions established the insertion of the transgene to be in the receptor protein tyrosine phosphatase kappa (RPTP-κ) and the laminin receptor 1 (ribosomal protein SA) pseudogene 1 locus. RPTP-κ expression in both GFP-labeled dorsal root ganglia and SG neurons raises the possibility that homophilic interactions of RPTP-κ contribute to establishment of connections between specific classes of primary afferent and SG neurons.</p>
},
	issn = {0021-9967},
	doi = {doi: 10.1002/cne.20709},
	author = {Hantman, Adam W. and Perl, Edward R}
}
@article {5904,
	title = {Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression.},
	journal = {The Journal of Neuroscience},
	volume = {24},
	year = {2004},
	month = {2004 Jan 28},
	pages = {836-42},
	abstract = {<p>The spinal substantia gelatinosa (SG) is known to be involved in the manipulation of nociceptive and thermal primary afferent input; however, the interrelationships of its neuronal components are poorly understood. As a step toward expanding understanding, we took a relatively unique approach by concentrating on a set of SG neurons selectively labeled by green fluorescent protein (GFP) in a transgenic mouse. These GFP-expressing SG neurons prove to have homogenous morphological and electrophysiological properties, are systematically spaced in the SG, contain GABA, receive C-fiber primary afferent input, and upregulate c-Fos protein in response to noxious stimuli. Together, the properties established for these GFP-labeled neurons are consistent with a modular SG organization in which afferent activity related to nociception or other C-fiber signaling are subject to integration/modulation by repeating, similar circuits of neurons.</p>
},
	keywords = {Animals, Biological Markers, Electrophysiology, gamma-Aminobutyric Acid, Ganglia, Green Fluorescent Proteins, Luminescent Proteins, Lysine, Mice, Nerve Fibers, Neurons, Pain Measurement, Patch-Clamp Techniques, Proto-Oncogene Proteins c-fos, Spinal, Substantia Gelatinosa, Transgenic, Unmyelinated},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.4221-03.2004},
	author = {Hantman, Adam W and van den Pol, Anthony N and Perl, Edward R}
}
