@article {2135,
	title = {LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites.},
	journal = {Nature Neuroscience},
	volume = {7},
	year = {2004},
	month = {2004 Feb},
	pages = {126-35},
	abstract = {<p>The propagation and integration of signals in the dendrites of pyramidal neurons is regulated, in part, by the distribution and biophysical properties of voltage-gated ion channels. It is thus possible that any modification of these channels in a specific part of the dendritic tree might locally alter these signaling processes. Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the activation of NMDA receptors. These changes favored the back-propagation of action potentials into this dendritic region with a subsequent boost in the Ca(2+) influx. Dendritic cell-attached patch recordings revealed a hyperpolarized shift in the inactivation curve of transient, A-type K(+) currents that can account for the enhanced excitability. These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function.</p>
},
	keywords = {Action Potentials, Animals, Calcium, Dendrites, Excitatory Postsynaptic Potentials, Hippocampus, Ion Channels, Long-Term Potentiation, Memory, N-Methyl-D-Aspartate, Neuronal Plasticity, Organ Culture Techniques, Patch-Clamp Techniques, Rats, Receptors},
	issn = {1097-6256},
	doi = {10.1002/cbic.201000254},
	author = {Frick, Andreas and Magee, Jeffrey and Johnston, Daniel}
}
@article {2138,
	title = {Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neurons.},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	volume = {23},
	year = {2003},
	month = {2003 Apr 15},
	pages = {3243-50},
	abstract = {<p>Oblique dendrites of CA1 pyramidal neurons predominate in stratum radiatum and receive approximately 80\% of the synaptic input from Schaffer collaterals. Despite this fact, most of our understanding of dendritic signal processing in these neurons comes from studies of the main apical dendrite. Using a combination of Ca2+ imaging and whole-cell recording techniques in rat hippocampal slices, we found that the properties of the oblique dendrites differ markedly from those of the main dendrites. These different properties tend to equalize the Ca2+ rise from single action potentials as they backpropagate into the oblique dendrites from the main trunk. Evidence suggests that this normalization of Ca2+ signals results from a higher density of a transient, A-type K+ current [I(K(A))] in the oblique versus the main dendrites. The higher density of I(K(A)) may have important implications for our understanding of synaptic integration and plasticity in these structures.</p>
},
	keywords = {4-Aminopyridine, Action Potentials, Animals, Calcium, Calcium Channel Blockers, Calcium Signaling, Dendrites, Electric Stimulation, Fluorescent Dyes, Hippocampus, Patch-Clamp Techniques, Potassium Channel Blockers, Potassium Channels, Pyramidal Cells, Rats, Sodium Channels, Sprague-Dawley, Tetrodotoxin},
	issn = {1529-2401},
	doi = {10.1002/cbic.201000254},
	author = {Frick, Andreas and Magee, Jeffrey and Koester, Helmut J and Migliore, Michele and Johnston, Daniel}
}
