@article {65115,
	title = {Effective dimensionality reduction for visualizing neural dynamics by laplacian eigenmaps.},
	journal = {Neural Computation},
	volume = {31},
	year = {2019},
	month = {2019 Jul},
	pages = {1356-1379},
	abstract = {<p>With the development of neural recording technology, it has become possible to collect activities from hundreds or even thousands of neurons simultaneously. Visualization of neural population dynamics can help neuroscientists analyze large-scale neural activities efficiently. In this letter, Laplacian eigenmaps is applied to this task for the first time, and the experimental results show that the proposed method significantly outperforms the commonly used methods. This finding was confirmed by the systematic evaluation using nonhuman primate data, which contained the complex dynamics well suited for testing. According to our results, Laplacian eigenmaps is better than the other methods in various ways and can clearly visualize interesting biological phenomena related to neural dynamics.</p>
},
	issn = {1530-888X},
	doi = {10.1162/neco_a_01203},
	author = {Sun, G and Zhang, S and Zhang, Y and Xu, K and Zhang, Q and Zhao, T and Zheng, X}
}
@article {1780,
	title = {Mammalian sweet taste receptors.},
	journal = {Cell},
	volume = {106},
	year = {2001},
	month = {2001 Aug 10},
	pages = {381-90},
	abstract = {<p>The sense of taste provides animals with valuable information about the quality and nutritional value of food. Previously, we identified a large family of mammalian taste receptors involved in bitter taste perception (the T2Rs). We now report the characterization of mammalian sweet taste receptors. First, transgenic rescue experiments prove that the Sac locus encodes T1R3, a member of the T1R family of candidate taste receptors. Second, using a heterologous expression system, we demonstrate that T1R2 and T1R3 combine to function as a sweet receptor, recognizing sweet-tasting molecules as diverse as sucrose, saccharin, dulcin, and acesulfame-K. Finally, we present a detailed analysis of the patterns of expression of T1Rs and T2Rs, thus providing a view of the representation of sweet and bitter taste at the periphery.</p>
},
	keywords = {Animals, Calcium Signaling, Cell Line, Cell Surface, Chromosomes, Cricetinae, Evolution, G-Protein-Coupled, Gene Expression Profiling, Genetic Complementation Test, Heterotrimeric GTP-Binding Proteins, Human, Humans, Messenger, Mice, Molecular, Molecular Sequence Data, Multigene Family, Pair 4, Phenylurea Compounds, Physical Chromosome Mapping, Receptors, RNA, Saccharin, Substrate Specificity, Sucrose, Sweetening Agents, Taste, Taste Buds, Thiazines, Transgenic},
	issn = {0092-8674},
	author = {Nelson, G and Hoon, M A and Chandrashekar, J and Zhang, Y and Ryba, N J and Zuker, C S}
}
