@article {1518,
	title = {Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.},
	journal = {Science},
	volume = {292},
	year = {2001},
	month = {2001 Apr 27},
	pages = {737-40},
	abstract = {<p>Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.</p>
},
	keywords = {Animals, Body Patterning, Cell Fusion, Cell Movement, Confocal, Drosophila, Drosophila Proteins, Embryo, Epidermis, Immunologic, Mesoderm, Microscopy, Muscles, Mutation, Nerve Tissue Proteins, Nonmammalian, Receptors, Signal Transduction, Stem Cells},
	issn = {0036-8075},
	doi = {10.1126/science.1058766},
	author = {Kramer, S G and Kidd, T and Simpson, J H and Goodman, C S}
}
@article {1520,
	title = {Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.},
	journal = {Neuron},
	volume = {28},
	year = {2000},
	month = {2000 Dec},
	pages = {753-66},
	abstract = {<p>Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robo mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robo, some other Slit receptor ensures that growth cones do not stay at the midline, even though they cross and recross it. Here we show that the Drosophila genome encodes three Robo receptors and that Robo and Robo2 have distinct functions, which together control repulsive axon guidance at the midline. The robo,robo2 double mutant is largely identical to slit.</p>
},
	keywords = {Animals, Axons, Cell Line, Cell Surface, Central Nervous System, Cloning, COS Cells, Dimerization, Down-Regulation, Drosophila, Drosophila Proteins, Gene Expression, Growth Cones, Humans, Immunologic, Insect Proteins, Insertional, Ligands, Membrane Proteins, Messenger, Molecular, Molecular Sequence Data, Mutagenesis, Nerve Tissue Proteins, Phenotype, Receptors, RNA},
	issn = {0896-6273},
	author = {Simpson, J H and Kidd, T and Bland, K S and Goodman, C S}
}
