@article {1519,
	title = {Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.},
	journal = {Cell},
	volume = {103},
	year = {2000},
	month = {2000 Dec 22},
	pages = {1019-32},
	abstract = {<p>Slit is secreted by midline glia in Drosophila and functions as a short-range repellent to control midline crossing. Although most Slit stays near the midline, some diffuses laterally, functioning as a long-range chemorepellent. Here we show that a combinatorial code of Robo receptors controls lateral position in the CNS by responding to this presumptive Slit gradient. Medial axons express only Robo, intermediate axons express Robo3 and Robo, while lateral axons express Robo2, Robo3, and Robo. Removal of robo2 or robo3 causes lateral axons to extend medially; ectopic expression of Robo2 or Robo3 on medial axons drives them laterally. Precise topography of longitudinal pathways appears to be controlled by a combination of long-range guidance (the Robo code determining region) and short-range guidance (discrete local cues determining specific location within a region).</p>
},
	keywords = {Animals, Cell Movement, Developmental, Drosophila, Drosophila Proteins, Gene Expression Regulation, Immunoelectron, Immunologic, Microscopy, Mutagenesis, Nerve Tissue Proteins, Nervous System, Neurons, Phenotype, Receptors},
	issn = {0092-8674},
	author = {Simpson, J H and Bland, K S and Fetter, R D and Goodman, C S}
}
@article {1520,
	title = {Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.},
	journal = {Neuron},
	volume = {28},
	year = {2000},
	month = {2000 Dec},
	pages = {753-66},
	abstract = {<p>Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robo mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robo, some other Slit receptor ensures that growth cones do not stay at the midline, even though they cross and recross it. Here we show that the Drosophila genome encodes three Robo receptors and that Robo and Robo2 have distinct functions, which together control repulsive axon guidance at the midline. The robo,robo2 double mutant is largely identical to slit.</p>
},
	keywords = {Animals, Axons, Cell Line, Cell Surface, Central Nervous System, Cloning, COS Cells, Dimerization, Down-Regulation, Drosophila, Drosophila Proteins, Gene Expression, Growth Cones, Humans, Immunologic, Insect Proteins, Insertional, Ligands, Membrane Proteins, Messenger, Molecular, Molecular Sequence Data, Mutagenesis, Nerve Tissue Proteins, Phenotype, Receptors, RNA},
	issn = {0896-6273},
	author = {Simpson, J H and Kidd, T and Bland, K S and Goodman, C S}
}
