@article {6455,
	title = {Multiple perceptible signals from a single olfactory glomerulus.},
	journal = {Nature Neuroscience},
	volume = {16},
	year = {2013},
	month = {2013 Sep 22},
	pages = {1687-91},
	abstract = {<p>Glomeruli are functional units in the olfactory system. The mouse olfactory bulb contains roughly 2,000 glomeruli, each receiving inputs from olfactory sensory neurons (OSNs) that express a specific odorant receptor gene. Odors typically activate many glomeruli in complex combinatorial patterns and it is unknown which features of neuronal activity in individual glomeruli contribute to odor perception. To address this, we used optogenetics to selectively activate single, genetically identified glomeruli in behaving mice. We found that mice could perceive the stimulation of a single glomerulus. Single-glomerulus stimulation was also detected on an intense odor background. In addition, different input intensities and the timing of input relative to sniffing were discriminated through one glomerulus. Our data suggest that each glomerulus can transmit odor information using identity, intensity and temporal coding cues. These multiple modes of information transmission may enable the olfactory system to efficiently identify and localize odor sources.</p>
},
	issn = {1546-1726},
	doi = {10.1038/nn.3519},
	author = {Smear, Matthew and Resulaj, Admir and Zhang, Jingji and Bozza, Thomas and Rinberg, Dmitry}
}
@article {4148,
	title = {Perception of sniff phase in mouse olfaction.},
	journal = {Nature},
	volume = {14},
	year = {2011},
	month = {2011 Oct 12},
	pages = {1039-44},
	abstract = {<p>Olfactory systems encode odours by which neurons respond and by when they respond. In mammals, every sniff evokes a precise, odour-specific sequence of activity across olfactory neurons. Likewise, in a variety of neural systems, ranging from sensory periphery to cognitive centres, neuronal activity is timed relative to sampling behaviour and/or internally generated oscillations. As in these neural systems, relative timing of activity may represent information in the olfactory system. However, there is no evidence that mammalian olfactory systems read such cues. To test whether mice perceive the timing of olfactory activation relative to the sniff cycle ({\textquoteright}sniff phase{\textquoteright}), we used optogenetics in gene-targeted mice to generate spatially constant, temporally controllable olfactory input. Here we show that mice can behaviourally report the sniff phase of optogenetically driven activation of olfactory sensory neurons. Furthermore, mice can discriminate between light-evoked inputs that are shifted in the sniff cycle by as little as 10 milliseconds, which is similar to the temporal precision of olfactory bulb odour responses. Electrophysiological recordings in the olfactory bulb of awake mice show that individual cells encode the timing of photoactivation in relation to the sniff in both the timing and the amplitude of their responses. Our work provides evidence that the mammalian olfactory system can read temporal patterns, and suggests that timing of activity relative to sampling behaviour is a potent cue that may enable accurate olfactory percepts to form quickly.</p>
},
	issn = {1476-4687},
	doi = {10.1038/nature10521},
	author = {Smear, Matthew and Shusterman, Roman and O{\textquoteright}Connor, Rodney and Bozza, Thomas and Rinberg, Dmitry}
}
