@article {67828,
	title = {A brainstem integrator for self-localization and positional homeostasis},
	journal = {Cell},
	volume = {185},
	year = {2022},
	month = {2022 Dec 22},
	pages = {5011-5027.e20},
	abstract = {<p>To accurately track self-location, animals need to integrate their movements through space. In amniotes, representations of self-location have been found in regions such as the hippocampus. It is unknown whether more ancient brain regions contain such representations and by which pathways they may drive locomotion. Fish displaced by water currents must prevent uncontrolled drift to potentially dangerous areas. We found that larval zebrafish track such movements and can later swim back to their earlier location. Whole-brain functional imaging revealed the circuit enabling this process of positional homeostasis. Position-encoding brainstem neurons integrate optic flow, then bias future swimming to correct for past displacements by modulating inferior olive and cerebellar activity. Manipulation of position-encoding or olivary neurons abolished positional homeostasis or evoked behavior as if animals had experienced positional shifts. These results reveal a multiregional hindbrain circuit in vertebrates for optic flow integration, memory of self-location, and its neural pathway to behavior.Competing Interest StatementThe authors have declared no competing interest.</p>
},
	doi = {10.1101/2021.11.26.468907},
	url = {https://www.biorxiv.org/content/early/2021/11/27/2021.11.26.468907},
	author = {Yang, En and Zwart, Maarten F. and Rubinov, Mikail and James, Benjamin and Wei, Ziqiang and Narayan, Sujatha and Vladimirov, Nikita and Mensh, Brett D. and Fitzgerald, James E. and Ahrens, Misha B.}
}
@article {49535,
	title = {Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.},
	journal = {Nature Methods},
	volume = {15},
	year = {2018},
	month = {2018 Nov 30},
	pages = {1117-1125},
	abstract = {<p>Whole-brain imaging allows for comprehensive functional mapping of distributed neural pathways, but neuronal perturbation experiments are usually limited to targeting predefined regions or genetically identifiable cell types. To complement whole-brain measures of activity with brain-wide manipulations for testing causal interactions, we introduce a system that uses measuredactivity patterns to guide optical perturbations of any subset of neurons in the same fictively behaving larval zebrafish. First, a light-sheet microscope collects whole-brain data that are rapidly analyzed by a distributed computing system to generate functional brain maps. On the basis of these maps, the experimenter can then optically ablate neurons and image activity changes across the brain. We applied this method to characterize contributions of behaviorally tuned populations to the optomotor response. We extended the system to optogenetically stimulate arbitrary subsets of neurons during whole-brain imaging. These open-source methods enable delineating the contributions of neurons to brain-wide circuit dynamics and behavior in individual animals.</p>
},
	doi = {10.1038/s41592-018-0221-x},
	author = {Vladimirov, Nikita and Wang, Chen and H{\"o}ckendorf, Burkhard and Pujala, Avinash and Tanimoto, Masashi and Mu, Yu and Yang, Chao-Tsung and Wittenbach, Jason and Freeman, Jeremy and Preibisch, Stephan and Koyama, Minoru and Keller, Philipp J and Ahrens, Misha B}
}
