@article {6927,
	title = {Non-redundant coding of aversive odours in the main olfactory pathway.},
	journal = {Nature},
	volume = {497},
	year = {2013},
	month = {2013 May 23},
	pages = {486-9},
	abstract = {<p>Many species are critically dependent on olfaction for survival. In the main olfactory system of mammals, odours are detected by sensory neurons that express a large repertoire of canonical odorant receptors and a much smaller repertoire of trace amine-associated receptors (TAARs). Odours are encoded in a combinatorial fashion across glomeruli in the main olfactory bulb, with each glomerulus corresponding to a specific receptor. The degree to which individual receptor genes contribute to odour perception is unclear. Here we show that genetic deletion of the olfactory Taar gene family, or even a single Taar gene (Taar4), eliminates the aversion that mice display to low concentrations of volatile amines and to the odour of predator urine. Our findings identify a role for the TAARs in olfaction, namely, in the high-sensitivity detection of innately aversive odours. In addition, our data reveal that aversive amines are represented in a non-redundant fashion, and that individual main olfactory receptor genes can contribute substantially to odour perception.</p>
},
	keywords = {Amines, Animals, Avoidance Learning, Female, G-Protein-Coupled, Male, Mice, Models, Neurological, Odorant, Odors, Olfactory Bulb, Olfactory Pathways, Olfactory Receptor Neurons, Predatory Behavior, Receptors, Smell, Urine},
	issn = {1476-4687},
	doi = {10.1038/nature12114},
	author = {Dewan, Adam and Pacifico, Rodrigo and Zhan, Ross and Rinberg, Dmitry and Bozza, Thomas}
}
@article {65017,
	title = {An olfactory subsystem that mediates high-sensitivity detection of volatile amines.},
	journal = {Cell Rep},
	volume = {2},
	year = {2012},
	month = {2012 Jul 26},
	pages = {76-88},
	abstract = {<p>Olfactory stimuli are detected by over 1,000 odorant receptors in mice, with each receptor being mapped to specific glomeruli in the olfactory bulb. The trace amine-associated receptors (TAARs) are a small family of evolutionarily conserved olfactory receptors whose contribution to olfaction remains enigmatic. Here, we show that a majority of the TAARs are mapped to a discrete subset of glomeruli in the dorsal olfactory bulb of the mouse. This TAAR projection is distinct from the previously described class I and class II domains, and is formed by a sensory neuron population that is restricted to express TAAR genes prior to choice. We also show that the dorsal TAAR glomeruli are selectively activated by amines at low concentrations. Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines.</p>
},
	keywords = {Amines, Animals, Female, Gene Targeting, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Multigene Family, Olfactory Pathways, Olfactory Perception, Olfactory Receptor Neurons, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Substrate Specificity, Volatile Organic Compounds, Volatilization},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2012.06.006},
	author = {Pacifico, Rodrigo and Dewan, Adam and Cawley, Dillon and Guo, Caiying and Bozza, Thomas}
}
