@article {45913,
	title = {Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites.},
	journal = {Science},
	volume = {268},
	year = {1995},
	month = {1995 Apr 14},
	pages = {297-300},
	abstract = {<p>The temporal and spatial profile of activity-evoked changes in membrane potential and intracellular calcium concentration in the dendrites of hippocampal CA1 pyramidal neurons was examined with simultaneous somatic and dendritic patch-pipette recording and calcium imaging experiments. Action potentials are initiated close to the soma of these neurons and backpropagate into the dendrites in an activity-dependent manner; those occurring early in a train propagate actively, whereas those occurring later fail to actively invade the distal dendrites. Consistent with this finding, dendritic calcium transients evoked by single action potentials do not significantly attenuate with distance from the soma, whereas those evoked by trains attenuate substantially. Failure of action potential propagation into the distal dendrites often occurs at branch points. Consequently, neighboring regions of the dendritic tree can experience different voltage and calcium signals during repetitive action potential firing. The influence of backpropagating action potentials on synaptic integration and plasticity will therefore depend on both the extent of dendritic branching and the pattern of neuronal activity.</p>
},
	keywords = {Action Potentials, Animals, Calcium, Calcium Channels, Dendrites, Ion Channel Gating, Neuronal Plasticity, Patch-Clamp Techniques, Pyramidal Cells, Rats, Rats, Wistar, Sodium Channels, Synapses, Tetrodotoxin},
	issn = {0036-8075},
	author = {Spruston, N and Schiller, Y and Stuart, G and Sakmann, B}
}
