@article {46421,
	title = {Caenorhabditis elegans innexins regulate active zone differentiation.},
	journal = {The Journal of Neuroscience},
	volume = {29},
	year = {2009},
	month = {2009 Apr 22},
	pages = {5207-17},
	abstract = {<p>In a genetic screen for active zone defective mutants in Caenorhabditis elegans, we isolated a loss-of-function allele of unc-7, a gene encoding an innexin/pannexin family gap junction protein. Innexin UNC-7 regulates the size and distribution of active zones at C. elegans neuromuscular junctions. Loss-of-function mutations in another innexin, UNC-9, cause similar active zone defects as unc-7 mutants. In addition to presumptive gap junction localizations, both UNC-7 and UNC-9 are also localized perisynaptically throughout development and required in presynaptic neurons to regulate active zone differentiation. Our mosaic analyses, electron microscopy, as well as expression studies suggest a novel and likely nonjunctional role of specific innexins in active zone differentiation in addition to gap junction formations.</p>
},
	keywords = {Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Differentiation, Connexins, Gap Junctions, Gene Expression Regulation, Developmental, Male, Membrane Proteins, Organisms, Genetically Modified, Presynaptic Terminals},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.0637-09.2009},
	author = {Yeh, Edward and Kawano, Taizo and Ng, Sharon and Fetter, Richard and Hung, Wesley and Wang, Ying and Zhen, Mei}
}
