@article {49182,
	title = {Transvection Goes Live-Visualizing Enhancer-Promoter Communication between Chromosomes.},
	journal = {Molecular Cell},
	volume = {70},
	year = {2018},
	month = {2018 Apr 19},
	pages = {195-196},
	abstract = {<p>Lim et\&nbsp;al. (2018) use live imaging in Drosophila embryos to show that enhancers can drive transcription from promoters on another chromosome when they are in close proximity. In addition, they show that multiple promoters can access the same enhancer without competition, potentially sharing a pool of factors in a transcriptional "hub."</p>
},
	issn = {1097-4164},
	doi = {10.1016/j.molcel.2018.04.004},
	author = {Tsai, Albert and Singer, Robert H and Crocker, Justin}
}
@article {6089,
	title = {TALE-mediated modulation of transcriptional enhancers in vivo.},
	journal = {Nature Methods},
	volume = {10},
	year = {2013},
	month = {2013 Jun 30},
	pages = {762-7},
	abstract = {<p>We tested whether transcription activator-like effectors (TALEs) could mediate repression and activation of endogenous enhancers in the Drosophila genome. TALE repressors (TALERs) targeting each of the five even-skipped (eve) stripe enhancers generated repression specifically of the focal stripes. TALE activators (TALEAs) targeting the eve promoter or enhancers caused increased expression primarily in cells normally activated by the promoter or targeted enhancer, respectively. This effect supports the view that repression acts in a dominant fashion on transcriptional activators and that the activity state of an enhancer influences TALE binding or the ability of the VP16 domain to enhance transcription. In these assays, the Hairy repression domain did not exhibit previously described long-range transcriptional repression activity. The phenotypic effects of TALER and TALEA expression in larvae and adults are consistent with the observed modulations of eve expression. TALEs thus provide a novel tool for detection and functional modulation of transcriptional enhancers in their native genomic context.</p>
},
	issn = {1548-7105},
	doi = {10.1038/nmeth.2543},
	author = {Crocker, Justin and Stern, David L}
}
