@article {67771,
	title = {A connectome of the  central complex reveals network motifs suitable for flexible navigation and context-dependent action selection.},
	journal = {eLife},
	volume = {10},
	year = {2021},
	month = {2021 Oct 26},
	abstract = {<p>Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which are experimentally challenging to study. In insects, recurrent circuit dynamics in a brain region called the central complex (CX) enable directed locomotion, sleep, and context- and experience-dependent spatial navigation. We describe the first complete electron-microscopy-based connectome of the CX, including all its neurons and circuits at synaptic resolution. We identified new CX neuron types, novel sensory and motor pathways, and network motifs that likely enable the CX to extract the fly{\textquoteright}s head-direction, maintain it with attractor dynamics, and combine it with other sensorimotor information to perform vector-based navigational computations. We also identified numerous pathways that may facilitate the selection of CX-driven behavioral patterns by context and internal state. The CX connectome provides a comprehensive blueprint necessary for a detailed understanding of network dynamics underlying sleep, flexible navigation, and state-dependent action selection.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.66039},
	author = {Hulse, Brad K and Haberkern, Hannah and Franconville, Romain and Turner-Evans, Daniel B and Takemura, Shin-ya and Wolff, Tanya and Noorman, Marcella and Dreher, Marisa and Dan, Chuntao and Parekh, Ruchi and Hermundstad, Ann M and Rubin, Gerald M and Jayaraman, Vivek}
}
@article {47092,
	title = {Central neural circuitry mediating courtship song perception in male Drosophila.},
	journal = {eLife},
	volume = {4},
	year = {2015},
	month = {2015 Sep 21},
	abstract = {<p>Animals use acoustic signals across a variety of social behaviors, particularly courtship. In Drosophila, song is detected by antennal mechanosensory neurons and further processed by second-order aPN1/aLN(al) neurons. However, little is known about the central pathways mediating courtship hearing. In this study, we identified a male-specific pathway for courtship hearing via third-order ventrolateral protocerebrum Projection Neuron 1 (vPN1) neurons and fourth-order pC1 neurons. Genetic inactivation of vPN1 or pC1 disrupts song-induced male-chaining behavior. Calcium imaging reveals that vPN1 responds preferentially to pulse song with long inter-pulse intervals (IPIs), while pC1 responses to pulse song closely match the behavioral chaining responses at different IPIs. Moreover, genetic activation of either vPN1 or pC1 induced courtship chaining, mimicking the behavioral response to song. These results outline the aPN1-vPN1-pC1 pathway as a labeled line for the processing and transformation of courtship song in males.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.08477},
	author = {Zhou, Chuan and Franconville, Romain and Vaughan, Alexander G and Robinett, Carmen C and Jayaraman, Vivek and Baker, Bruce S}
}
