@article {68516,
	title = {Hippocampal representations of foraging trajectories depend upon spatial context.},
	journal = {Nature Neuroscience},
	volume = {25},
	year = {2022},
	month = {2022 Dec 02},
	pages = {1693-1705},
	abstract = {<p>Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and evaluation of trajectories for learning. Do hippocampal representations differentially contribute to experience-dependent learning of trajectories across spatial and relational contexts? In this study, we trained mice to navigate to a hidden target in a physical arena or manipulate a joystick to a virtual target to collect delayed rewards. In a navigational context, calcium imaging in freely moving mice revealed that synchronous CA1 reactivation was retrospective and important for evaluation of prior navigational trajectories. In a non-navigational context, reactivation was prospective and important for initiation of joystick trajectories, even in the same animals trained in both contexts. Adaptation of trajectories to a new target was well-explained by a common learning algorithm in which hippocampal activity makes dissociable contributions to reinforcement learning computations depending upon spatial context.</p>
},
	keywords = {Animals, Hippocampus, Mental Recall, Mice, Prospective Studies, Retrospective Studies, Spatial Navigation},
	issn = {1546-1726},
	doi = {10.1038/s41593-022-01201-7},
	author = {Jiang, Wan-Chen and Xu, Shengjin and Dudman, Joshua T}
}
@article {65696,
	title = {Hindbrain double-negative feedback mediates palatability-guided food and water consumption.},
	journal = {Cell},
	volume = {182},
	year = {2020},
	month = {2020 Sep 17},
	pages = {1589-1605},
	abstract = {<p>Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLC neurons) as a polysynaptic convergence node from separate energy-sensitive and hydration-sensitive cell populations. We develop methods for stable hindbrain calcium imaging in free-moving mice, which show that periLC neurons are tuned to ingestive behaviors and respond similarly to food or water consumption. PeriLC neurons are scalably inhibited by palatability and homeostatic need during consumption. Inhibition of periLC neurons is rewarding and increases consumption by enhancing palatability and prolonging ingestion duration. These properties comprise a double-negative feedback relationship that sustains food or water consumption without affecting food- or water-seeking. PeriLC neurons are a hub between hunger and thirst that specifically controls motivation for food and water ingestion, which is a factor that contributes to hedonic overeating and obesity.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2020.07.031},
	author = {Gong, Rong and Xu, Shengjin and Hermundstad, Ann and Yu, Yang and Sternson, Scott M}
}
