@article {49473,
	title = {Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1.},
	journal = {Cell reports},
	volume = {25},
	year = {2018},
	month = {2018 Oct 16},
	pages = {640-650.e2},
	abstract = {<p>Neural network remodeling underpins the ability to remember life experiences, but little is known about the long-term plasticity of neural populations. To study how the brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter of neural plasticity based on an enhanced form of the synaptic activity-responsive element (E-SARE) within the Arc promoter to track thousands of CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes characteristic patterns of ensemble neural plasticity, but with each encounter, the set of activated cells gradually evolves. After repeated exposures, the plasticity patterns evoked by an individual environment progressively stabilize. Compared with young adults, plasticity patterns in aged mice are less specific to individual environments and less stable across repeat experiences. Long-term consolidation of hippocampal plasticity patterns may support long-term memory formation, whereas weaker consolidation in aged subjects might reflect declining memory function.</p>
},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2018.09.064},
	author = {Attardo, Alessio and Lu, Ju and Kawashima, Takashi and Okuno, Hiroyuki and Fitzgerald, James E and Bito, Haruhiko and Schnitzer, Mark J}
}
@article {45177,
	title = {Light-sheet functional imaging in fictively behaving zebrafish.},
	journal = {Nature Methods},
	volume = {11},
	year = {2014},
	month = {2014 Jul 27},
	pages = {883-4},
	abstract = {<p>The processing of sensory input and the generation of behavior involves large networks of neurons, which necessitates new technology for recording from many neurons in behaving animals. In the larval zebrafish, light-sheet microscopy can be used to record the activity of almost all neurons in the brain simultaneously at single-cell resolution. Existing implementations, however, cannot be combined with visually driven behavior because the light sheet scans over the eye, interfering with presentation of controlled visual stimuli. Here we describe a system that overcomes the confounding eye stimulation through the use of two light sheets and combines whole-brain light-sheet imaging with virtual reality for fictively behaving larval zebrafish.</p>
},
	issn = {1548-7105},
	doi = {10.1038/nmeth.3040},
	author = {Vladimirov, Nikita and Mu, Yu and Kawashima, Takashi and Bennett, Davis V and Yang, Chao-Tsung and Looger, Loren L and Keller, Philipp J and Freeman, Jeremy and Ahrens, Misha B}
}
