@article {65856,
	title = {Theoretical principles for illuminating sensorimotor processing with brain-wide neuronal recordings.},
	journal = {Current Opinion in Neurobiology},
	volume = {65},
	year = {2020},
	month = {2020 Nov 25},
	pages = {138-145},
	abstract = {<p>Modern recording techniques now permit brain-wide sensorimotor circuits to be observed at single neuron resolution in small animals. Extracting theoretical understanding from these recordings requires principles that organize findings and guide future experiments. Here we review theoretical principles that shed light onto brain-wide sensorimotor processing. We begin with an analogy that conceptualizes principles as streetlamps that illuminate the empirical terrain, and we illustrate the analogy by showing how two familiar principles apply in new ways to brain-wide phenomena. We then focus the bulk of the review on describing three more principles that have wide utility for mapping brain-wide neural activity, making testable predictions from highly parameterized mechanistic models, and investigating the computational determinants of neuronal response patterns across the brain.</p>
},
	issn = {1873-6882},
	doi = {10.1016/j.conb.2020.10.021},
	author = {Biswas, Tirthabir and Bishop, William E and Fitzgerald, James E}
}
@article {56201,
	title = {Threshold-based ordering of sequential actions during Drosophila courtship.},
	journal = {Current Biology : CB},
	volume = {29},
	year = {2019},
	month = {2019 Jan 07},
	pages = {426-34},
	abstract = {<p>Goal-directed animal behaviors are typically composed of sequences of motor actions whose order and timing are critical for a successful outcome. Although numerous theoretical models for sequential action generation have been proposed, few have been supported by the identification of control neurons sufficient to elicit a sequence. Here, we identify a pair of descending neurons that coordinate a stereotyped sequence of engagement actions during Drosophila melanogaster male courtship behavior. These actions are initiated sequentially but persist cumulatively, a feature not explained by existing models of sequential behaviors. We find evidence consistent with a ramp-to-threshold mechanism, in which increasing neuronal activity elicits each action independently at successively higher activity thresholds.</p>
},
	issn = {1879-0445},
	doi = {10.1016/j.cub.2018.12.019},
	author = {McKellar, Claire E and Lillvis, Joshua L and Bath, Daniel E and Fitzgerald, James E and Cannon, John G and Simpson, Julie H and Dickson, Barry J}
}
