@article {49520,
	title = {Brain-wide organization of neuronal activity and convergent sensorimotor transformations in larval zebrafish.},
	journal = {Neuron},
	volume = {100},
	year = {2018},
	month = {2018 Nov 21},
	pages = {876-890.e5},
	abstract = {<p>Simultaneous recordings of large populations of neurons in behaving animals allow detailed observation of high-dimensional, complex brain activity. However, experimental approaches often focus on singular behavioral paradigms or brain areas. Here, we recorded whole-brain neuronal activity of larval zebrafish presented with a battery of visual stimuli while recording fictive motor output. We identified neurons tuned to each stimulus type and motor output and discovered groups of neurons in the anterior hindbrain that respond to different stimuli eliciting similar behavioral responses. These convergent sensorimotor representations were only weakly correlated to instantaneous motor activity, suggesting that they critically inform, but do not directly generate, behavioral choices. To catalog brain-wide activity beyond explicit sensorimotor processing, we developed an unsupervised clustering technique that organizes neurons into functional groups. These analyses enabled a broad overview of the functional organization of the brain and revealed numerous brain nuclei whose neurons exhibit concerted activity patterns.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2018.09.042},
	author = {Chen, Xiuye and Mu, Yu and Hu, Yu and Kuan, Aaron T and Nikitchenko, Maxim and Randlett, Owen and Chen, Alex B and Gavornik, Jeffery P and Sompolinsky, Haim and Engert, Florian and Ahrens, Misha B}
}
@article {48386,
	title = {From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response.},
	journal = {Cell},
	volume = {167},
	year = {2016},
	month = {2016 11 03},
	pages = {947-960.e20},
	abstract = {<p>Detailed descriptions of brain-scale sensorimotor circuits underlying vertebrate behavior remain elusive. Recent advances in zebrafish neuroscience offer new opportunities to dissect such circuits via whole-brain imaging, behavioral analysis, functional perturbations, and network modeling. Here, we harness these tools to generate a brain-scale circuit\&nbsp;model of the optomotor response, an orienting behavior evoked by visual motion. We show that such motion is processed by diverse neural response types distributed across multiple brain regions. To transform sensory input into action, these regions sequentially integrate eye- and direction-specific sensory streams, refine representations via interhemispheric inhibition, and demix locomotor instructions to independently drive turning and forward swimming. While experiments revealed many neural response types throughout the brain, modeling identified the dimensions of functional connectivity most critical for the behavior. We thus reveal how distributed neurons collaborate to generate behavior and illustrate a paradigm for distilling functional circuit models from whole-brain data.</p>
},
	keywords = {Animals, Brain, Feedback, Sensory, Neural Pathways, Neuroimaging, Neurons, Swimming, Visual Perception, Zebrafish},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2016.10.019},
	author = {Naumann, Eva A and Fitzgerald, James E and Dunn, Timothy W and Rihel, Jason and Sompolinsky, Haim and Engert, Florian}
}
