@article {46918,
	title = {Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons.},
	journal = {Nature Neuroscience},
	year = {2015},
	month = {2015 Jul 13},
	abstract = {<p>Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps.</p>
},
	issn = {1546-1726},
	doi = {10.1038/nn.4062},
	author = {Bittner, Katie C and Grienberger, Christine and Vaidya, Sachin P and Milstein, Aaron D and Macklin, John J and Suh, Junghyup and Tonegawa, Susumu and Magee, Jeffrey C}
}
@article {47277,
	title = {Cortex commands the performance of skilled movement.},
	journal = {eLife},
	volume = {4},
	year = {2015},
	month = {2015 Dec 3},
	abstract = {<p>Mammalian cerebral cortex is accepted as being critical for voluntary motor control, but what functions depend on cortex is still unclear. Here we used rapid, reversible optogenetic inhibition to test the role of cortex during a head-fixed task in which mice reach, grab, and eat a food pellet. Sudden cortical inhibition blocked initiation or froze execution of this skilled prehension behavior, but left untrained forelimb movements unaffected. Unexpectedly, kinematically normal prehension occurred immediately after cortical inhibition even during rest periods lacking cue and pellet. This {\textquoteright}rebound{\textquoteright} prehension was only evoked in trained and food-deprived animals, suggesting that a motivation-gated motor engram sufficient to evoke prehension is activated at inhibition{\textquoteright}s end. These results demonstrate the necessity and sufficiency of cortical activity for enacting a learned skill.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.10774},
	author = {Guo, Jian-Zhong and Graves, Austin R and Guo, Wendy W and Zheng, Jihong and Lee, Allen and Rodr{\'\i}guez-Gonz{\'a}lez, Juan and Li, Nuo and Macklin, John J and Phillips, James W and Mensh, Brett D and Branson, Kristin and Hantman, Adam W}
}
