@article {49415,
	title = {Defective cortex glia plasma membrane structure underlies light-induced epilepsy in  mutants.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {115},
	year = {2018},
	month = {2018 Sep 05},
	pages = {E8919-28},
	abstract = {<p>Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, and no good genetic animal models have been identified as yet. Here, we show an animal model of PSE, in , owing to defective cortex glia. The cortex glial membranes are severely compromised in ceramide phosphoethanolamine synthase ()-null mutants and fail to encapsulate the neuronal cell bodies in the neuronal cortex. Expression of human sphingomyelin synthase 1, which synthesizes the closely related ceramide phosphocholine (sphingomyelin), rescues the cortex glial abnormalities and PSE, underscoring the evolutionarily conserved role of these lipids in glial membranes. Further, we show the compromise in plasma membrane structure that underlies the glial cell membrane collapse in mutants and leads to the PSE phenotype.</p>
},
	issn = {1091-6490},
	doi = {10.1073/pnas.1808463115},
	author = {Kunduri, Govind and Turner-Evans, Daniel and Konya, Yutaka and Izumi, Yoshihiro and Nagashima, Kunio and Lockett, Stephen and Holthuis, Joost and Bamba, Takeshi and Acharya, Usha and Acharya, Jairaj K}
}
@article {49176,
	title = {A novel sheet-like virus particle array is a hallmark of Zika virus infection.},
	journal = {Emerging Microbes \& Infections},
	volume = {7},
	year = {2018},
	month = {2018 Apr 25},
	pages = {69},
	abstract = {<p>Zika virus (ZIKV) is an emerging flavivirus that caused thousands of human infections in recent years. Compared to other human flaviviruses, ZIKV replication is not well understood. Using fluorescent, transmission electron, and focused ion beam-scanning electron microscopy, we examined ZIKV replication dynamics in Vero 76 cells and in the brains of infected laboratory mice. We observed the progressive development of a perinuclear flaviviral replication factory both in vitro and in vivo. In vitro, we illustrated the ZIKV lifecycle from particle cell entry to egress. ZIKV particles assembled and aggregated in an induced convoluted membrane structure and ZIKV strain-specific membranous vesicles. While most mature virus particles egressed via membrane budding, some particles also likely trafficked through late endosomes and egressed through membrane abscission. Interestingly, we consistently observed a novel sheet-like virus particle array consisting of a single layer of ZIKV particles. Our study further defines ZIKV replication and identifies a novel hallmark of ZIKV infection.</p>
},
	issn = {2222-1751},
	doi = {10.1038/s41426-018-0071-8},
	author = {Liu, Jun and Kline, Brandon A and Kenny, Tara A and Smith, Darci R and Soloveva, Veronica and Beitzel, Brett and Pang, Song and Lockett, Stephen and Hess, Harald F and Palacios, Gustavo and Kuhn, Jens H and Sun, Mei G and Zeng, Xiankun}
}
