@article {49474,
	title = {Expanding the optogenetics toolkit by topological inversion of rhodopsins.},
	journal = {Cell},
	volume = {175},
	year = {2018},
	month = {2018 Oct 16},
	pages = {1131-40},
	abstract = {<p>Targeted manipulation of activity in specific populations of neurons is important for investigating the neural circuit basis of behavior. Optogenetic approaches using light-sensitive microbial rhodopsins have permitted manipulations to reach a level of temporal precision that is enabling functional circuit dissection. As demand for more precise perturbations to serve specific experimental goals increases, a palette of opsins with diverse selectivity, kinetics, and spectral properties will be needed. Here, we introduce a novel approach of "topological engineering"-inversion of opsins in the plasma membrane-and demonstrate that it can produce variants with unique functional properties of interest for circuit neuroscience. In one striking example, inversion of a Channelrhodopsin variant converted it from a potent activator into a fast-acting inhibitor that operates as a cation pump. Our findings argue that membrane topology provides a useful orthogonal dimension of protein engineering that immediately permits as much as a doubling of the available toolkit.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2018.09.026},
	author = {Brown, Jennifer and Behnam, Reza and Coddington, Luke and Tervo, D G R and Martin, Kathleen and Proskurin, Mikhail and Kuleshova, Elena and Park, Junchol and Phillips, James and Bergs, Amelie C F and Gottschalk, Alexander and Dudman, Joshua T and Karpova, Alla Y}
}
@article {49258,
	title = {Science holds the key to unlocking economic success.},
	year = {2018},
	month = {2018 Jun 07},
	abstract = {<div>The 2008 crisis should have led us to reshape how our economy works. But a decade on, what has really changed? The public knows that the same attitude that got us into the previous economic crisis will not bring us long-term prosperity, yet there is little vision from our leaders of what the future should look like. Our politicians are sleeping, yet have no dreams. To solve this, we must change emphasis from creating {\textquotedblleft}growth{\textquotedblright} to creating the future: the former is an inevitable product of the latter.</div>
},
	url = {https://www.telegraph.co.uk/business/2018/06/07/science-holds-key-unlocking-economic-success/},
	author = {Phillips, James and Phillips, Matthew}
}
