@article {49368,
	title = {Building a functional connectome of the  central complex.},
	journal = {eLife},
	volume = {7},
	year = {2018},
	month = {2018 Aug 20},
	abstract = {<p>The central complex is a highly conserved insect brain region composed of morphologically stereotyped neurons that arborize in distinctively shaped substructures. The region is implicated in a wide range of behaviors and several modeling studies have explored its circuit computations. Most studies have relied on assumptions about connectivity between neurons based on their overlap in light microscopy images. Here, we present an extensive functional connectome of Drosophila melanogaster{\textquoteright}s central complex at cell-type resolution. Using simultaneous optogenetic stimulation, calcium imaging and pharmacology, we tested the connectivity between 70 presynaptic-to-postsynaptic cell-type pairs. We identi1ed numerous inputs to the central complex, but only a small number of output channels. Additionally, the connectivity of this highly recurrent circuit appears to be sparser than anticipated from light microscopy images. Finally, the connectivity matrix highlights the potentially critical role of a class of bottleneck interneurons. All data is provided for interactive exploration on a website.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.37017},
	author = {Franconville, Romain and Beron, Celia and Jayaraman, Vivek}
}
