@article {49527,
	title = {MYC induces a hybrid energetics program early in cell reprogramming.},
	journal = {Stem Cell Reports},
	volume = {11},
	year = {2018},
	month = {2018 Dec 11},
	pages = {1479-92},
	abstract = {<p>Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood. By using cellular, biochemical, protein array, metabolomic, and respirometry analyses, we found that c-MYC establishes a robust bivalent energetics program early in cell reprogramming. Cells prone to undergo reprogramming exhibit high mitochondrial membrane potential and display a hybrid metabolism. We conclude that MYC proteins orchestrate a rewiring of somatic cell metabolism early in cell reprogramming, whereby somatic cells acquire the phenotypic plasticity necessary for their transition to pluripotency in response to either intrinsic or external cues.</p>
},
	issn = {2213-6711},
	doi = {10.1016/j.stemcr.2018.10.018},
	author = {Prieto, Javier and Seo, Arnold Y and Le{\'o}n, Marian and Santacatterina, Fulvio and Torresano, Laura and Palomino-Sch{\"a}tzlein, Martina and Gim{\'e}nez, Karen and Vallet-S{\'a}nchez, Azahara and Ponsoda, Xavier and Pineda-Lucena, Antonio and Cuezva, Jos{\'e} M and Lippincott-Schwartz, Jennifer and Torres, Josema}
}
