@article {49584,
	title = {Stem cells repurpose proliferation to contain a breach in their niche barrier.},
	journal = {eLife},
	volume = {7},
	year = {2018},
	month = {2018 Dec 06},
	abstract = {<p>Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically change their transcriptome independent of bacterial invasion and become capable of directly signaling to and recruiting immune cells. Additionally, these stem cells elevate cell cycle transcripts which reduce their quiescence threshold, enabling them to selectively proliferate within this microenvironment of immune distress cues. However, rather than mobilizing to fuel new tissue regeneration, these ectopically proliferative stem cells remain within their niche to contain the breach. Together, our findings expose a potential communication relay system that operates from the niche to the stem cells to the immune system and back. The repurposing of proliferation by these stem cells patch the breached barrier, stoke the immune response and restore niche integrity.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.41661},
	author = {Lay, Kenneth and Yuan, Shaopeng and Gur-Cohen, Shiri and Miao, Yuxuan and Han, Tianxiao and Naik, Shruti and Pasolli, H Amalia and Larsen, Samantha B and Fuchs, Elaine}
}
