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2 Publications

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    09/19/18 | Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila.
    Dolan M, Belliart-Guérin G, Bates AS, Frechter S, Lampin-Saint-Amaux A, Aso Y, Roberts RJ, Schlegel P, Wong A, Hammad A, Bock D, Rubin GM, Preat T, Placais P, Jefferis GS
    Neuron. 2018 Sep 19;100(3):651-68. doi: 10.1016/j.neuron.2018.08.037

    The behavioral response to a sensory stimulus may depend on both learned and innate neuronal representations. How these circuits interact to produce appropriate behavior is unknown. In Drosophila, the lateral horn (LH) and mushroom body (MB) are thought to mediate innate and learned olfactory behavior, respectively, although LH function has not been tested directly. Here we identify two LH cell types (PD2a1 and PD2b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. These neurons are required for aversive memory retrieval and modulated by training. Connectomics data demonstrate that PD2a1 and PD2b1 neurons also receive direct input from food odor-encoding neurons. Consistent with this, PD2a1 and PD2b1 are also necessary for unlearned attraction to some odors, indicating that these neurons have a dual behavioral role. This provides a circuit mechanism by which learned and innate olfactory information can interact in identified neurons to produce appropriate behavior.

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    08/26/18 | Neural circuit basis of aversive odour processing in drosophila from sensory input to descending output.
    Paavo Huoviala , Michael-John Dolan , Fiona M. Love , Shahar Frechter , Ruairí J.V. Roberts , Zane Mitrevica , Philipp Schlegel , Alexander Shakeel Bates , Yoshinori Aso , Tiago Rodrigues , Hannah Cornwall , Marcus Stensmyr , Davi Bock , Gerald M. Rubin , Marta Costa , Gregory S.X.E. Jefferis
    bioRxiv. 2018 Aug 26:. doi: 10.1101/394403

    Evolution has tuned the nervous system of most animals to produce stereotyped behavioural responses to ethologically relevant stimuli. For example, female Drosophila avoid laying eggs in the presence of geosmin, an odorant produced by toxic moulds. Using this system, we now identify third order olfactory neurons that are essential for an innate aversive behaviour. Connectomics data place these neurons in the context of a complete synaptic circuit from sensory input to descending output. We find multiple levels of valence-specific convergence, including a novel form of axo-axonic input onto second order neurons conveying another danger signal, the pheromone of parasitoid wasps. However we also observe a massive divergence as geosmin-responsive second order olfactory neurons connect with a diverse array of ∼75 cell types. Our data suggest a transition from a labelled line organisation in the periphery to one in which olfactory information is mapped onto many different higher order populations with distinct behavioural significance.

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