Structural Membrane Biochemistry and method development in cryo EM.
Our laboratory studies the structures of membrane proteins important in homeostasis and signaling. We develop new tools in structural biology, namely MicroED as a new method for cryo EM, to facilitate the study of such membrane proteins to atomic resolution from vanishingly small crystals.
Reichow SL, Clemens DM., Freites JA., Németh-Cahalan KL., Heyden M., Tobias DJ., Hall JE*. and Gonen T Allosteric mechanism of water channel gating by Ca2+-calmodulin. Nature Structural and Molecular Biology. 20 (9): 1085 - 1092 (2013).