Structural Membrane Biochemistry and method development in cryo EM.
Our laboratory studies the structures of membrane proteins important in homeostasis and signaling. We develop new tools in structural biology, namely MicroED as a new method for cryo EM, to facilitate the study of such membrane proteins to atomic resolution from vanishingly small crystals.
Rodriguez A.J., Ivanova M., Sawaya MR., Cascio D., Reyes F., Shi D., Sangwan S., Guenther EL., Johnson L, Zhang M., Jiang L., Arbing M., Nannega B., Hattne J., Whitelegge J., Brewster AS., Messerschmidt M., Boutet S., Sauter NK., Gonen T* and Eisenberg D* Structure of the toxic core of a-synuclein from invisible crystals. Nature - In Press (2015).
Additional Gonen Lab sites
Effective September 1, Tamir Gonen is an HHMI Investigator at University of California, Los Angeles. For more information on his work at UCLA, please visit: http://www.mbi.ucla.edu/faculty/tamir-gonen/