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    Baker Lab
    03/01/82 | Sex determination in Drosophila melanogaster: analysis of transformer-2 , a sex-transforming locus.
    Baker B, Belote J
    Proceedings of the National Academy of Sciences of the United States of America. 1982 Mar;79(5):1568-72

    The transformer-2 (tra-2) locus is one of a set of regulatory loci that control sex determination in Drosophila melanogaster. Temperature-shift experiments with temperature-sensitive tra-2 mutants demonstrate that within single cell lineages tra-2+ function is required at several times, and probably continuously, during development for the occurrence of a series of determinative decisions necessary for female sexual differentiation. Analysis of the effects of tra-2 in the genital disc demonstrates that the tra-2+ function is necessary in females both to prevent male sexual differentiation and to permit female differentiation. These and other results support the model that the tra-2+ and tra+ loci act to control the expression of the bifunctional doublesex (dsx) locus.

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