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2 Publications

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    Druckmann LabMagee Lab
    10/22/18 | Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior.
    Ranganathan GN, Apostolides PF, Harnett MT, Xu N, Druckmann S, Magee JC
    Nature Neuroscience. 2018 Oct 22;21(11):1583-90. doi: 10.1038/s41593-018-0254-6

    Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex produce a diverse and distributed representation that is required for mice to adapt their whisking motor strategy to changing sensory cues. The optogenetic perturbation degraded single-neuron selectivity and network population encoding through a selective inhibition of active dendritic integration. Together the data indicate that active dendritic integration in pyramidal neurons produces a nonlinearly mixed network representation of joint sensorimotor parameters that is used to transform sensory information into motor commands during adaptive behavior. The prevalence of the layer 5 cortical circuit motif suggests that this is a general circuit computation.

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    Druckmann LabMagee Lab
    02/05/14 | Structured synaptic connectivity between hippocampal regions.
    Shaul Druckmann , Feng L, Lee B, Yook C, Zhao T, Magee JC, Kim J
    Neuron. 2014 Feb 5;81:629-40. doi: 10.1016/j.neuron.2013.11.026

    The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.

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