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2 Publications

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    Tjian Lab
    11/19/10 | A new focus on plant sciences.
    McCormick SJ, Tjian R
    Science. 2010 Nov 19;330(6007):1021. doi: 10.1073/pnas.1100640108
    Tjian Lab
    08/01/10 | Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.
    Goodrich JA, Tjian R
    Nature Reviews. Genetics. 2010 Aug;11:549-58. doi: 10.1073/pnas.1100640108

    The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with ’non-prototypical’ subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.

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