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2 Publications

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    08/17/89 | The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells.
    Moses K, Ellis MC, Rubin GM
    Nature. 1989 Aug 17;340(6234):531-6. doi: 10.1186/gb-2007-8-7-r145

    Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a single neuronal cell type.

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    04/01/89 | Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction.
    Montell C, Rubin GM
    Neuron. 1989 Apr;2(4):1313-23. doi: 10.1186/gb-2007-8-7-r145

    Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that trp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells.

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