custom | custom
Filter
facetapi-Q2b17qCsTdECvJIqZJgYMaGsr8vANl1n | block
Associated Lab
- Remove Eddy/Rivas Lab filter Eddy/Rivas Lab
facetapi-PV5lg7xuz68EAY8eakJzrcmwtdGEnxR0 | block
Publication Date
facetapi-021SKYQnqXW6ODq5W5dPAFEDBaEJubhN | block
Type of Publication
general_search_page-panel_pane_1 | views_panes
1 Publications
Showing 1-1 of 1 resultsYour Criteria:
Eddy/Rivas LabScientific Computing Software
01/01/17 |
A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs.
Nature Methods. 2017 Jan 31;14(1):45-8
Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.