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1 Publications

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    04/22/13 | Clonal development and organization of the adult Drosophila central brain.
    Yu H, Awasaki T, Schroeder MD, Long F, Yang JS, He Y, Ding P, Kao J, Wu GY, Peng H, Myers G, Lee T
    Current biology : CB. 2013 Apr 22;23:633-43. doi: 10.1016/j.cub.2013.02.057

    BACKGROUND: The insect brain can be divided into neuropils that are formed by neurites of both local and remote origin. The complexity of the interconnections obscures how these neuropils are established and interconnected through development. The Drosophila central brain develops from a fixed number of neuroblasts (NBs) that deposit neurons in regional clusters. RESULTS: By determining individual NB clones and pursuing their projections into specific neuropils, we unravel the regional development of the brain neural network. Exhaustive clonal analysis revealed 95 stereotyped neuronal lineages with characteristic cell-body locations and neurite trajectories. Most clones show complex projection patterns, but despite the complexity, neighboring clones often coinnervate the same local neuropil or neuropils and further target a restricted set of distant neuropils. CONCLUSIONS: These observations argue for regional clonal development of both neuropils and neuropil connectivity throughout the Drosophila central brain.

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