Our ultimate goal is to provide a mechanistic understanding of a behaviorally relevant brain function.
To this end we are attempting to produce biophysically based explanations of the information-processing and storage capabilities of single and small networks of neurons. We use a variety of optical (two-photon transmitter uncaging, single and two-photon ChR2/NpHR activation, two photon Ca2+ imaging) and electrical (dual whole-cell recordings, cell-attached and outside-out patches) techniques in the various projects.
CA1 pyramidal dendrites with ChR2 expression in layer 2 Enterhinal cortex axons. –Andrasfalvy
CA1 pyramidal neuron. –Makara
CA3 pyramidal neuron –glutamate uncaging. –Makara
CA1 pyramidal neuron with ChR2 expression in PV interneurons. –Losonczy
CA1 pyramidal neuron with ChR2 expression in schaffer collaterals. –Magee