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18 Results

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    Tools
    AAV-Flex
    We have developed a widely used Cre-dependent viral vector utilizing a genetic element called a FLEX switch. Plasmids are available from Addgene.com...
    Tools
    CaMPARI
    CaMPARI (Calcium Modulated Photoactivatable Ratiometric Integrator) is a photoconvertible protein construct that enables imaging of the integrated calcium activity of large populations of cells...
    Tools
    Carbon-Based Fluorogenics
    The use of fluorescence technologies for biochemi-cal and biological research has exploded in recent years. Chemical fluorophores can enable super-resolution microscopy, high-throughput screening...
    Tools
    CASFISH: DNA labeling with CRISPR/Cas9
    Genomic DNA in cells is highly folded and organized in three dimensions. Detection and visualization of genomic DNA is widely accomplished through the use of various ...
    Tools
    Chimeric Ligand-Gated Ion Channels
    In the nervous system, ligand-gated ion channels (LGICs) transduce chemical signals into electrical activity that communicates information. Implicated in many neurological disorders, LGICs are...
    Tools
    Drosophilia Genetic Tools
    Rubin lab Plasmid Constructs are available from Addgene, which has distributed over 430 of the plasmids listed below.   Plasmids from Pfeiffer et al. 2008 and Pfeiffer...
    Tools
    GCaMP
    Current Iterations: GCaMP3, GCaMP5, GCaMP6 Fluorescent calcium indicators are an important tool used to detect and measure calcium, an essential regulator of cellular signaling. These...
    Tools
    Glucose Sensor
    Inventors at Janelia have developed a strategy for the creation of genetically encoded, intensity-based fluorescent sensors and an associated unique set of analytical tools that can measure...
    Tools
    iGluSnFR
    The major neurotransmitter in the brain, glutamate is an important signaling molecule in biological organisms. The ability to visualize and quantitate glutamate transients is broadly useful to...
    Tools
    Janelia Fluor® Dyes
    Bright and photostable fluorescent labels are critical tools for the life sciences.  A key determinant of fluorophore performance is the quantum yield (QY); dyes with improved QY values are...