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    Red-Shifted and Fluorinated Dyes "JF3" for Advanced Bioimaging
    Overview Fluorination and structural tuning of rhodamine scaffolds have yielded a powerful new class of bright, red-shifted fluorescent dyes for live-cell and super-resolution microscopy....
    Tools
    rsCaMPARI
    The rsCaMPARI technology is a groundbreaking sensor technology that provides a reversible method for marking and tracking neuronal activity. Based on photoconvertible fluorescent proteins,...
    Tools
    Single-Fluorescent Protein Biosensors
    Maltose Sensor - Glutamate Sensor - Phosphonate Sensor Inventors at Howard Hughes Medical Center’s Janelia Research Campus have produced a general strategy for the creation of...
    Tools
    smartFISH
    FISH Background Fluorescent in situ hybridization (FISH) is a powerful diagnostic and discovery tool for identifying the genomic status of samples through the localization...
    Tools
    Spontaneously blinking JFb dyes
    Overview Applying the tuning strategies inherent in the Janelia Fluor® platform to hydroxymethyl (HM) derivatives of rhodamines yields a palette of spontaneously blinking dyes for super-...
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    The Janelia Fluor® Dyes: Bright and Cell-Permeable Small-Molecule Fluorophores
    Overview The Janelia Fluor® dyes are a next-generation small-molecule fluorophore platform that combines superior brightness, photostability, and cell permeability with unprecedented modularity,...
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    The JFX™ Dyes
    Overview The JFX dye platform enhances the performance of Janelia Fluor® dyes by introducing deuterium at key positions, boosting brightness and extending photostability without altering their...
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    Voltron and Positron
    Voltron 2.0 and Positron 2.0 are state-of-the-art genetically encoded voltage indicators (GEVIs) for use in vivo or in vitro. Developed and optimized at...
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    WHaloCaMP: Modular, Bright, and Multiplexable Chemigenetic Calcium Indicators
    Overview WHaloCaMP sensors integrate the high-performance Janelia Fluor dyes with genetically engineered HaloTag proteins for modular, tunable calcium imaging in living systems. This platform...