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    2 Photon Random Access Mesoscope
    Researchers at HHMI Janelia Research Campus have designed and built a 2-photon random access mesoscope (2P-RAM) that provides rapid imaging anywhere within a large tissue volume. ...
    3D iPalm
    This invention combines interferometry and photoactivated localization microscopy (PALM) to create a new light microscopy technique that provides sub-20-nm, three-dimensional localization....
    Adaptive Optics via Pupil Image Segmentation
    Microscope Adaptive Optics by rear pupil masking, adaptive optics for high-resolution imaging in biological tissue. This technology advances light microscopy's resolution and depth limit...
    Enhanced FIB-SEM
    Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) is an advanced technique to make 3D images of biological cells in tissues with superior z-axis (vertical) resolution, generating easily...
    Although multiple electron microscopic techniques can achieve ~10 nm isotropic resolution, none are well-suited to image volumes at or above 1 mm3. Structural imaging at this scale opens new...
    High Speed Scanning Image
    Laser scanning microscopy (LSM) is an essential tool for imaging biological specimens, and two-photon LSM is the standard for imaging in vivo or in other highly scattering media. However, imaging...
    Immersion Reflection Microscope Objective
    The standard reflection objective is designed to work in air with reasonably high resolution. It is a lightweight, simple structure (only one or two mirrors are needed) with little chromatic...
    Biological imaging techniques such as two-photon microscopy are playing a key role in driving new advances in understanding the behavior of tissues, cells, and molecules.  However, when...
    Kilohertz frame-rate tomographic 2-photon microscope
    This microscope images megapixel fields of view at over 1000 Hz within scattering tissue by scanning excitation lines at multiple angles and recovering images computationally. It can image large...
    Lattice Light Microscopy
    The Lattice Light involves using a Bessel beam to illuminate a sample with light sheets that are sufficiently thin to achieve isotropic 3D resolution high-speed 3D fluorescent imaging. As a result...