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Eva Pastalkova

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My work focuses on episodic and spatial memory. I study neuronal activity in animals while they perform a memory task in an environment that reduces or eliminates external stimuli. I also study neural activity while the animals sleep. I am particularly interested in the following questions:What are the mechanisms of the internally organized activity in the dorsal and ventral hippocampus and its major input-ouput structure, the entorhinal cortex, during a hippocampus-dependent memory task? What are the mechanisms organizing the spontaneous patterns of sleep, and how do they organize memories acquired during the performance of a memory task? I study the mechanisms that internally organize neuronal activity in two ways. First, I record activity from two or more anatomically connected regions and study the relationship between the signals generated within each of these regions. Second, I interfere with the neuronal network within one region and study the consequences of this on activity in the other region. I employ various techniques to interfere with neuronal activity: light-induced excitation of channelrhodopsin-expressing neurons, light-induced suppression of halorhodopsin-expressing neurons, local change of brain temperature, and electrical stimulation.   Biographical Data: 2010 - Fellow, Janelia Research Campus, HHMI, Ashburn, VA, USA 2004 -2009 post-doc, lab of Prof. György Buzsáki, MD., PhD., Rutgers University, Newark, NJ, USA 2003-2004 research scholar at SUNY Downstate Medical Center, Brooklyn, NY, USA advisor: André A. Fenton, PhD. and Todd C. Sacktor, MD. 2003 Ph.D. in Neuronscience, Charles University, advisior: Jan Bureš, MD., PhD. 2002 research scholar at SUNY Downstate Medical Center, Brooklyn, NY advisor: André A. Fenton, PhD. 1999 visiting student at the Dep. of Psychology, Zurich University, Switzerland 1999   M.Sc. in Neuroscience, Charles University, Pragueadvisior: Jan Bureš, MD., PhD.