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3 Janelia Publications

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    05/22/17 | Angular velocity integration in a fly heading circuit.
    Turner-Evans D, Wegener S, Rouault H, Franconville R, Wolff T, Seelig JD, Druckmann S, Jayaraman V
    eLife. 2017 May 22;6:. doi: 10.7554/eLife.23496

    Many animals maintain an internal representation of their heading as they move through their surroundings. Such a compass representation was recently discovered in a neural population in the Drosophila melanogaster central complex, a brain region implicated in spatial navigation. Here, we use two-photon calcium imaging and electrophysiology in head-fixed walking flies to identify a different neural population that conjunctively encodes heading and angular velocity, and is excited selectively by turns in either the clockwise or counterclockwise direction. We show how these mirror-symmetric turn responses combine with the neurons' connectivity to the compass neurons to create an elegant mechanism for updating the fly's heading representation when the animal turns in darkness. This mechanism, which employs recurrent loops with an angular shift, bears a resemblance to those proposed in theoretical models for rodent head direction cells. Our results provide a striking example of structure matching function for a broadly relevant computation.

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    05/22/17 | Development of photostable fluorophores for molecular imaging.
    Zheng Q, Lavis LD
    Current Opinion in Chemical Biology. 2017 May 22;39:32-38. doi: 10.1016/j.cbpa.2017.04.017

    Advances in fluorescence microscopy promise to unlock details of biological systems with high spatiotemporal precision. These new techniques also place a heavy demand on the 'photon budget'-the number of photons one can extract from a sample. Improving the photostability of small molecule fluorophores using chemistry is a straightforward method for increasing the photon budget. Here, we review the (sometimes sparse) efforts to understand the mechanism of fluorophore photobleaching and recent advances to improve photostability through reducing the propensity for oxidation or through intramolecular triplet-state quenching. Our intent is to inspire a more thorough mechanistic investigation of photobleaching and the use of precise chemistry to improve fluorescent probes.

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    05/22/17 | Spatial Memory: Mice Quickly Learn a Safe Haven.
    Egnor SE
    Current Biology : CB. 2017 May 22;27(10):R388-R390. doi: 10.1016/j.cub.2017.04.007

    New work on innate escape behavior shows that mice spontaneously form a spatially precise memory of the location of shelter, which is laid down quickly and updated continuously.

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