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1 Janelia Publications

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    01/01/17 | A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs.
    Rivas E, Clements J, Eddy SR
    Nature Methods. 2017 Jan 31;14(1):45-8

    Many functional RNAs have an evolutionarily conserved secondary structure. Conservation of RNA base pairing induces pairwise covariations in sequence alignments. We developed a computational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quantitatively tests whether covariation analysis supports the presence of a conserved RNA secondary structure. R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.

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