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2 Janelia Publications

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    12/12/17 | Chemogenetic tools for causal cellular and neuronal biology.
    Atasoy D, Sternson SM
    Physiological Reviews. 2017 Dec 12:. doi: 10.1152/physrev.00009.2017

    Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.

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    07/27/17 | Raphe circuits on the menu.
    Yang H, Sternson SM
    Cell. 2017 Jul 27;170(3):409-10. doi: 10.1016/j.cell.2017.07.017

    The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN.

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