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3 Janelia Publications

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    04/26/19 | A neural circuit encoding the experience of copulation in female Drosophila.
    Shao L, Chung P, Wong A, Siwanowicz I, Kent CF, Long X, Heberlein U
    Neuron. 2019 Apr 26;102(5):1025. doi: 10.1016/j.neuron.2019.04.009

    Female behavior changes profoundly after mating. In Drosophila, the mechanisms underlying the long-term changes led by seminal products have been extensively studied. However, the effect of the sensory component of copulation on the female's internal state and behavior remains elusive. We pursued this question by dissociating the effect of coital sensory inputs from those of male ejaculate. We found that the sensory inputs of copulation cause a reduction of post-coital receptivity in females, referred to as the "copulation effect." We identified three layers of a neural circuit underlying this phenomenon. Abdominal neurons expressing the mechanosensory channel Piezo convey the signal of copulation to female-specific ascending neurons, LSANs, in the ventral nerve cord. LSANs relay this information to neurons expressing myoinhibitory peptides in the brain. We hereby provide a neural mechanism by which the experience of copulation facilitates females encoding their mating status, thus adjusting behavior to optimize reproduction.

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    04/25/19 | Parametric amplification of reversible transverse susceptibility in single domain magnetic nanoparticles.
    El Bidweihy H, Smith RD, Barbic M
    AIP Advances. 2019 Apr 25;9:045031. doi: 10.1063/1.5079980

    We propose, model, and experimentally demonstrate the enhancement of reversible transverse susceptibility in single domain magnetic nanoparticles through the principle of parametric amplification. It has previously been demonstrated that properly oriented anisotropic single domain magnetic nanoparticles have an appreciable peak in transverse susceptibility at the particle anisotropy field. Here we show theoretically and experimentally that an additional parametric AC magnetic field applied at a proper phase and at twice the frequency (2f) of the transverse field further enhances transverse susceptibility peaks through the process of parametric amplification. We model this effect numerically and describe it through the energy formalism of the single magnetic domain Stoner-Wohlfarth model. The proper phase relationships of the transverse and parametric fields to obtain either parametric amplification or attenuation of the transverse susceptibility signals are also described. We experimentally demonstrate such parametric tuning of transverse susceptibility in single domain magnetic nanoparticles of a commercial audio tape in a prototypical inductive transverse susceptibility set-up.
     

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    04/01/19 | Multimodal in vivo brain electrophysiology with integrated glass microelectrodes.
    Hunt DL, Lai C, Smith RD, Lee AK, Harris TD, Barbic M
    Nature Biomedical Engineering. 2019 Apr 01;3(9):741-53. doi: 10.1038/s41551-019-0373-8

    Electrophysiology is the most used approach for the collection of functional data in basic and translational neuroscience, but it is typically limited to either intracellular or extracellular recordings. The integration of multiple physiological modalities for the routine acquisition of multimodal data with microelectrodes could be useful for biomedical applications, yet this has been challenging owing to incompatibilities of fabrication methods. Here, we present a suite of glass pipettes with integrated microelectrodes for the simultaneous acquisition of multimodal intracellular and extracellular information in vivo, electrochemistry assessments, and optogenetic perturbations of neural activity. We used the integrated devices to acquire multimodal signals from the CA1 region of the hippocampus in mice and rats, and show that these data can serve as ground-truth validation for the performance of spike-sorting algorithms. The microdevices are applicable for basic and translational neurobiology, and for the development of next-generation brain-machine interfaces.

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