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1 Janelia Publications

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    Sternson Lab
    06/01/22 | Development of an adrenocortical cell model of calcium signaling modulation to decipher the molecular mechanisms responsible for primary aldosteronism
    BakhtaFedlaoui , Teresa Cosentino , Zeina R. Al Sayed , Isabelle Giscos-Douriez , Fabio L. Fernandes-Rosa , Jean-SébastienHulot , Chris Magnus , Scott M. Sternson , Maria Christina Zennaro , Sheerazed Boulkroun
    Archives of Cardiovascular Diseases Supplements. 2022 Jun 01;14(2):160. doi: 10.1016/j.acvdsp.2022.04.153

    Primary aldosteronism (PA) is the most frequent form of secondary hypertension. The identification of germline or somatic mutations in different genes coding for ion channels and defines PA as a channelopathy. These mutations promote activation of calcium signaling, the main trigger for aldosterone biosynthesis.

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