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    Betzig LabLavis Lab
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    11/18/11 | Facile and general synthesis of photoactivatable xanthene dyes.
    Wysocki LM, Grimm JB, Tkachuk AN, Brown TA, Betzig E, Lavis LD
    Angewandte Chemie. 2011 Nov 18;50:11206-9. doi: 10.1002/anie.201104571

    Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates.

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