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1 Janelia Publications

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    02/01/15 | Theta sequences are essential for internally generated hippocampal firing fields.
    Wang Y, Romani S, Lustig B, Leonardo A, Pastalkova E
    Nature Neuroscience. 2015 Feb;18(2):282-8. doi: 10.1038/nn.3904

    Sensory cue inputs and memory-related internal brain activities govern the firing of hippocampal neurons, but which specific firing patterns are induced by either of the two processes remains unclear. We found that sensory cues guided the firing of neurons in rats on a timescale of seconds and supported the formation of spatial firing fields. Independently of the sensory inputs, the memory-related network activity coordinated the firing of neurons not only on a second-long timescale, but also on a millisecond-long timescale, and was dependent on medial septum inputs. We propose a network mechanism that might coordinate this internally generated firing. Overall, we suggest that two independent mechanisms support the formation of spatial firing fields in hippocampus, but only the internally organized system supports short-timescale sequential firing and episodic memory.

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